Early stages of peroxisomal protein import
Wczesne etapy importu białek do peroksysomów
Lipiński, Oskar

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The analysis of the anatomical variability of the internal iliac artery with particular emphasis on its implications in gynecological practice
Analiza zmienności anatomicznych tętnicy biodrowej wewnętrznej ze szczególnym uwzględnieniem implikacji w praktyce ginekologicznej
Hajdyła, Paweł

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Filozofia moralności Johna D. Caputo
John D. Caputo’s moral philosophy
Mickiewicz, Adriana

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Biopolimerowe systemy dostarczania temozolomidu dla potrzeb leczenia uzupełniającego w pooperacyjnej terapii wysokozłośliwych glejaków mózgu
Biopolymeric-based temozolomide delivery systems for adjuvant treatment purposes in postsurgical therapy of high-grade gliomas
Krajcer, Aleksandra

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Assignment of the right of priority : towards common international standards
Przeniesienie prawa pierwszeństwa do uzyskania patentu : w kierunku wspólnych standardów międzynarodowych
Barycki, Michał

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Investigation of magnetic properties and magnetocaloric effect in the $RE_{5}$$T_{2}$$In_{4}$ (RE = Gd-Tm, T - transition metal = Pt, Pd, Rh) intermetallics
Badanie właściwości magnetycznych oraz efektu magnetokalorycznego w związkach międzymetalicznych $RE_{5}$$T_{2}$$In_{4}$(RE = Gd–Tm, T - metal przejściowy = Pt, Pd, Rh)
Hayyu, Altifani

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In vitro - in vivo extrapolation and correlation of the absorption process after topical drug administration : numerical experiment with the use of PBPK models
Ekstrapolacja oraz korelacja in vitro - in vivo procesu wchłaniania leków po podaniu na skórę : eksperyment numeryczny z wykorzystaniem modeli PBPK
Krumpholz, Laura

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Contrasting effects of clozapine and risperidone on cholesterol metabolism, synaptic proteins, and transcriptional regulation in human LUHMES neurons
Rybczyński, Piotr; Cacała, Radosław; Cepil, Zuzanna; Fic, Ewelina; Romańska, Weronika; Marczak, Lukasz; Pustelny, Katarzyna; Kędracka-Krok, Sylwia
Antipsychotic drugs elicit complex cellular responses in neurons, yet the molecular mechanisms underlying their actions remain incompletely understood. Here, we employed deep proteomic profiling (DDA/DIA-MS) in LUHMES-derived dopaminergic neurons to explore the distinct proteomic profile induced by clozapine and risperidone. Pathway analysis revealed that clozapine robustly upregulated lipid metabolic pathways, particularly those involved in cholesterol and fatty acid biosynthesis. Conversely, risperidone primarily enhanced oxidative phosphorylation and modulated synaptic architecture and protein metabolic-pathways. Functional enrichment further indicated that clozapine promotes sterol metabolism, neuronal viability, and neurite outgrowth - hallmarks of neurotrophic activity - while simultaneously suppressing neurotransmission. Importantly, quantitative analysis of the nuclear subproteome enabled us to map these opposing regulatory hubs with high precision. Mechanistically, clozapine induced a transcriptionally repressive state, marked by downregulation of chromatin-opening factors CHD5 and DPF3 (BAF complex components) and HMGN1. In parallel, upregulation of the transcriptional repressor CIC reinforced this repressive signature, suggesting diminished chromatin accessibility. Furthermore, downregulation of activity-dependent regulators CRTC3 and JUNB pointed to an attenuation of excitability-driven gene expression. In contrast, risperidone upregulated TCF4, TCF7L1, FOS, HMGN1, and coactivators RREB1 and NCOA3, promoting Wnt signaling, chromatin accessibility and synaptic plasticity. Taken together, our data unveil distinct proteomic, transcriptional and epigenetic programs orchestrated by clozapine and risperidone, providing novel molecular insights into their divergent clinical actions.DOI: 10.1007/s12035-025-05515-y

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Conditional uncorrelation equals independence
Tarłowski, Dawid
DOI: 10.1016/j.jmaa.2025.130175

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On the dimension of orbits of matrix pencils under strict equivalence
De Terán, Fernando; Dopico, Froilán M.; Pagacz, Patryk
We prove that, given two matrix pencils 𝐿 and 𝑀, if 𝑀 belongs to the closure of the orbit of 𝐿 under strict equivalence, then the dimension of the orbit of 𝑀 is smaller than or equal to the dimension of the orbit of 𝐿, and the equality is only attained when 𝑀 belongs to the orbit of 𝐿. Our proof uses only the majorization involving the eigenstructures of 𝐿 and 𝑀 which characterizes the inclusion relationship between orbit closures, together with the formula for the codimension of the orbit of a pencil in terms of its eigenstruture.DOI: 10.1016/j.aml.2025.109695

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Novel cyanobacterial strains modulate morphophysiological traits of Lemna trisulca : insights from short- and long-term interactions
Kamiński, Ariel; Lelito, Bartosz; Panou, Manthos; Pappas, Dimitris; Panteris, Emmanuel; Gkelis, Spyros
DOI: 10.1016/j.marpolbul.2025.118632

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Exploring maximum likelihood and Bayesian approaches for two-dimensional image restoration : a machine learning perspective
Topolnicki, Kacper; Sharma, Sushil; Volkotrub, Yuriy; Das, Manish
DOI: 10.1016/j.cpc.2025.109913

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From recruitment to retention of young doctors : a comparative analysis of policies in Poland and the United Kingdom
Michalska, Kamila; Aquines, Alejandro Gonzalez; McVey, Lynn; Clark, Gaynor; Domagała, Alicja
DOI: 10.1016/j.healthpol.2025.105513

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Reporting guidelines can be used to foster reporting of evidence-based research principles : a cross-sectional study
Kabić, Tea; Šimundić Munitić, Marija; Weerasekara, Ishanka; Bała, Małgorzata; Zając, Joanna; Briel, Matthias; Pieper, Dawid; Puljak, Livia
DOI: 10.1016/j.jclinepi.2025.112008

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Fine-tuning 5-HT7 receptor selectivity, inverse agonism, and metabolic stability of new (aryloxy)ethyl-piperidines toward antidepressant and pro-cognitive properties
Canale, Vittorio; Blicharz-Futera, Klaudia; Bijata, Monika; Cavalco, Natalie G.; Partyka, Anna; Stefaniak, Matylda; Kamiński, Michał; Satała, Grzegorz; Warszycki, Dawid; Lanham, Janelle K.; Gołębiowska, Joanna; Gawlik, Maciej; Smolik, Magdalena; Bijata, Krystian; Jastrzębska-Więsek, Magdalena; Kurczab, Rafał; Bojarski, Andrzej J.; Walczak, Maria; McCorvy, John D.; Włodarczyk, Jakub; Popik, Piotr; Zajdel, Paweł
DOI: 10.1016/j.ejmech.2025.118369

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Qian, Maosheng; Li, Ruoyuan; Adamski, Andrzej; Sojka, Zbigniew; Liu, Zhangpei; Liu, Zhiming
Catalytic oxidation technology is considered one of the most promising techniques for the catalytic removal of toluene, with the key lies in the design of efficient and cost-effective catalysts. In recent years, various catalysts have been investigated for the catalytic oxidation of toluene. However, the complexity of the practical flue gas components and the requirement for continuous high-temperature operation impose higher demands on catalyst stability and anti-deactivation performance. While some reviews have mentioned the stability issue of VOCs catalysts, few studies have specifically focused on and systematically summarized the diverse deactivation factors and corresponding mitigation strategies for the catalytic oxidation of toluene. This review specifically addresses these issues by presenting recent advances in the catalytic oxidation of toluene, focusing on the chemical stability, thermal stability, and deactivation resistance of the catalyst. The key reaction mechanisms (Eley-Rideal mechanism, Langmuir-Hinshelwood mechanism and Mars-van Krevelen mechanism) are outlined, along with a thorough analysis of major deactivation factors, including thermal sintering, carbon deposition, and the detrimental effects of $H_{2}O, SO_{2}, CO_{2}$, and chlorine. Strategies for designing robust catalysts, such as optimizing active phase components, supports, physicochemical properties, and structural engineering, are systematically discussed. Some catalysts with high activity have also demonstrated significant stability improvements (e.g., the stability of single-atom catalysts). Moreover, regeneration methods for deactivated catalysts are critically reviewed. Finally, the current research progress and future challenges in this field are evaluated. This review aims to guide the design of oxidation catalysts with superior stability and higher operational efficiency under realistic industrial conditions.DOI: 10.1016/j.fuel.2025.136887

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Postulation of lines in $\mathbb{P}^{3}$ revisited
Dumnicki, Marcin; Le Van, Mikołaj; Malara, Grzegorz; Szemberg, Tomasz; Szpond, Justyna; Tutaj-Gasińska, Halszka
DOI: 10.1016/j.jsc.2025.102525

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Transformation of 5-chloro- and 5-bromo-2-cyanopyridine to amides and iminonitriles at the Mo(IV) center
Jurowska, Anna; Koprowska, Martyna; Bogdał, Weronika; Hodorowicz, Maciej; Szklarzewicz, Janusz
The reaction of $K_{3}Na[Mo(CN)_{4}O_{2}]·6H_{2}O$ complex with 5-chloro-2-cyanopyridine (5cl2py) and 5-bromo-2-cyanopyridine (5br2py), results in isolation of 4 new compounds, which were characterized by single X-ray crystal structure measurements, elemental analyses, IR and UV-Vis spectroscopy methods. Dimeric complex with the formula $(PPh_{4})_{4}[Mo(CN)_{3}O(μ-CN)Mo(CN)_{4}(H_{2}O)]·5cl2py·5H_{2}O·EtOH$ was isolated for the first time. The exchange of cyanido ligands for bidentate organic ligands, in this type of complexes, is largely pH dependent. Careful control of the reaction environment made it possible to obtain a modified organic ligand in which the nitrile group was hydrolyzed to the amide group (pH ca 8), or transformed, due to presence of cyanides in solution, to imino(5-chloropyridin-2-yl)acetonitrile (5cl2pya) or imino(5-bromopyridin-2-yl)acetonitrile (5br2pya), respectively. Two complexes with the formulas $(PPh_{4})_{2}[Mo(CN)_{3}O(5cl2pya)]·5cl2py$ and $(PPh_{4})_{2}[Mo(CN)_{3}O(5br2pya)]·5br2py$ (pH ca 10) were isolated. In these compounds, the 5cl2pya (or 5br2pya) was coordinated to the metal center as N,N-donating ligand, in which the modification of the nitrile group is discussed in detail in the paper.DOI: 10.1016/j.molstruc.2025.143979

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A fool's errand? : quantifying democratic fragility
Sawicka, Monika; McQuay, Mark
The chapter reviews selected democracy indices, as well as rankings of phenomena closely related to the stability of democratic regimes. It outlines the main controversies surrounding efforts to measure the condition of democratic regimes across the world and current trends in quantitative studies, along with considerations regarding the applicability of datasets to a project focused on the state of democratic fragility. The review of data provided in selected democratic rankings serves to outline a fragility map based on quantifiable indicators that reflect the features of democratic institutions, political elites and civil society, as well as a broad range of unfavourable conditions affecting democratic systems. In the final section, the ratings assigned in the indices to the states analysed in the chapters of the second part of the book are briefly outlined. This will allow us to highlight the limitations and shortfalls of quantitative assessments of democracy and the necessity to extend them through qualitative analysis.DOI: 10.4324/9781003512509-4

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Gruszczak, Artur; Sawicka, Monika; Zdeb, Aleksandra
Democracy remains susceptible to fragility. Despite its reputation as “the worst form of government except for all those others”, establishing and maintaining a democracy is a challenging endeavour. Once a democracy is formed, it is not destined to remain in that form indefinitely. The concept of fragility encapsulates the inherent instability of democracy, which is constantly evolving in response to a multitude of external and internal pressures. This volume explored the pertinence of the term ‘fragile’ to express the state of contemporary democratic regimes, proposed a coherent understanding of democratic fragility and looked at various manifestations of fragility across the world. Our claim is that fragility constitutes an attribute of democratic regimes and, as such, is unavoidable. Yet, what varies among different systems and fluctuates over time is the degree of fragility. The foundations and principles of democracy are increasingly under threat from those who seek to weaken them, not only for the purpose of seizing power and resources, but also in the name of the old-new catch-all term ‘security’, overused not only by dictators but also by populist democratic leaders.DOI: 10.4324/9781003512509-17

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